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KMID : 0644120190320010001
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Journal of Oriental Gynecology
2019 Volume.32 No. 1 p.1 ~ p.14
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Effect of Bombycis Corpus on Male Reproductive Dysfunction Caused by Aging
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Kim Hyung-Jun
Ahn Sang-Hyun
Ahn Ha-Young
Park Sun-Young
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Abstract
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Objectives: This study was designed to investigate the effect of Bombycis corpus on reproductive dysfunction caused by aging.
Methods: The experimental group was divided into three groups: a control group consisting of 8-week-old male ICR mice without any treatment, An aging-elicited group (AE group) consisting of 50-week-old ICR male mice without any treatment, and a Bombycis corpus treatment group (BC group) consisting of 50-week-old ICR male mice with treatment Bombycis corpus extract (0.78 g/kg/day) for 6 months. After 6 months, histochemistry and immunohistochemistry of the testis were performed to investigate the effects of Bombycis corpus on the reproductive dysfunction caused by aging.
Results: In the first step, Bombycis corpus increased spermatogenesis and distribution of sertoli cells in the seminiferous tubule, increased BrdU positive reaction in the spermatogonium at the basal part of the seminiferous tubule, and decreased the apoptosis of Sertoli cells in the seminiferous tubule. In addition, Bombycis corpus increased AR positive in Sertoli cells and 17β-HSD positive in leydig cells. Finally, Bombycis corpus decreased 8-OHdG positivite reaction in the spermatids of the seminiferous lumen, caspase-3 positivity in leydig cells, and HDAC1 positivite reaction in sertoli cells.
Conclusions: These results suggest that Bombycis corpus increases spermatogenesis, decreases apoptosis of leydig cells and Sertoli cells, increases the production and action of testosterone in the testis, and inhibits DNA damages and DNA transcripts decrease in the testis, Thereby improving reproductive dysfunction caused by aging.
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KEYWORD
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Bombycis Corpus (BC) , Reproductive Dysfunction , 17β-HSD , Androgen Receptor, 8-OHdG
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